A Novel Dual HDAC6 and Tubulin Inhibitor, MPT0B451, Displays Anti-tumor Ability in Human Cancer Cells in Vitro and in Vivo
The combination cancer therapy is a new strategy to circumvent drug resistance for the treatment ivoryjinelle.com of high metastasis and advanced malignancies.Herein, we developed a synthesized compound MPT0B451 that display inhibitory effect against histone deacetylase (HDAC) 6 and tubulin assembly.Our data demonstrated that MPT0B451 significantly